New Product Announcement | OrganoidpleX Medium (Immune Cell Co-culture Medium for Tumor Organoids) Coming Soon
Publication Date：2024-08-14
Foreword
Tumor organoids, as a novel 3D cellular disease model, can more authentically reproduce the biological characteristics of tumors, serving as a valuable tool for studying tumor behavior and screening new drugs. In the field of tumor research, understanding the tumor microenvironment and its interactions with the immune system is key to advancing cancer treatment. Therefore, to further explore the interactions between tumors and immune cells, we provide a specially designed co-culture medium for tumor organoids and immune cells.
This product is designed to meet researchers' demand for precise models in tumor immunology studies. The medium not only supports the growth and development of tumor organoids but also effectively maintains the activity and function of immune cells, thereby simulating the authentic tumor-immune microenvironment found in vivo.
Product Introduction
bioGenousTM OrganoidpleX Medium is a meticulously designed low-serum medium containing essential components for supporting tumor organoid growth, supplemented with specific factors that enhance immune cell function. It provides an optimized environment for co-incubation between tumor organoids and immune cells, more accurately reflecting the in vivo immune microenvironment. Utilizing this medium facilitates deeper insights into tumor immune escape mechanisms, evaluation of novel immunotherapy strategies, and screening of potential drug targets.
Product Features
Optimized Nutritional Composition
Supports the growth and maintenance of tumor organoids while providing essential growth factors and cytokines for immune cells.
Simulates In Vivo Immune Environment
Contains specific factors that modulate immune cell function to mimic authentic immune responses.
Broad Compatibility
Suitable for diverse tumor organoid and immune cell types, offering exceptional flexibility and broad applicability.
Product Data Presentation
Figure 1 Comparison of organoids and PBMCs after 3 days of co-culture
Comparison of co-cultures of lung adenocarcinoma organoids (LAC), colorectal cancer organoids (CRC), and gastric cancer organoids (GC) in vitro. Scale Bar: 50μm.
Colorectal cancer organoids co-cultured with Jurkat cells in vitro for two days.
Figure 2 Comparison of colorectal cancer cells co-cultured with Jurkat cells in vitro for two days
Fluorescent images of co-cultures with colorectal cancer and Jurkat cells at an effector-to-target ratio of 5:1, along with analysis of average caspase-3/7 fluorescence intensity; Colorectal cancer normal culture group; Colorectal cancer group overexpressing PD-L1 after overnight stimulation with IFN-γ.
