bioGenous™ G-27-VA is a customized version of bioGenous™ G-27, free of Vitamin A (retinyl acetate). It is an optimized serum-free supplement designed for organoid and neural cell culture systems where precise control over Vitamin A levels is required. Retinoic acid, the active metabolite of Vitamin A, plays a critical role in the growth and differentiation of various cell types. However, for specific lineages of organoid or neural cell cultures—particularly those sensitive to retinoic acid—the removal of Vitamin A helps maintain stem cell pluripotency and reduces unwanted differentiation. This product can be used with bioGenous™ organoid basal medium series (B213151, B213152, B213153) and other necessary growth factors to formulate a complete culture medium for organoid or cell cultures.