Unit 01-02 & 09-12, 8th Floor, Building 22, No. 388 Xinping Street, Suzhou Industrial Park, Suzhou Area, Jiangsu Pilot Free Trade Zone, China
Immune Microenvironment Co-culture Model
We develop organoid models that simulate the tumor immune microenvironment, enabling in-depth analysis of immune escape mechanisms and immunotherapy responses. This provides innovative solutions for the development of immunotherapies.
Organoid Immune Co-culture Model Simulates Tumor Immune Microenvironment in Humans: By co-culturing activated T cells with organoids, a co-culture model of the tumor immune microenvironment is established. Activated T cells derived from PBMCs are co-cultured with organoids at different Effect/Target ratio in coated 96-well plates to observe the killing effects under varying ratios. Subsequently, the co-culture is repeated at a determined Effect/Target Ratio, with parallel setups of PD-1 inhibitor treatment groups, chemotherapy drug treatment groups, and combination treatment groups for efficacy testing. This model simulates immune escape mechanisms and immunotherapy responses in the human body.
Preliminary experiment of Effect/Target Ratio
Bright-field Data from Formal Experiment at 5:1 Effect/Target Ratio
Fluorescence Imaging Data from Formal Experiment at 5:1 Effect/Target Ratio
