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bioGenous BIOTECH Inc,

Leading Organoid CRDMO Technology Platform

One-stop Supplier

 

 

bioGenous Biotechnology, Inc. is deeply committed to advancing foundational technological innovations in the organoid industry. It possesses globally leading, self-developed intellectual property in organoids and disease models, along with a GMP pharmaceutical-grade production technology system. Its main products include organoid culture reagents covering 23 types of normal tissues and 18 types of tumors, intelligent scenario-based equipment supporting the whole process of organoid construction, culture, and detection across multiple stages, and a flexible CRDMO technology platform tailored for pharmaceutical clients. Upholding the corporate vision of "Pioneering Pharmaceutical Innovation, Sharing Model Value," bioGenous is dedicated to providing standardized, pharmaceutical-grade upstream organoid solutions for the global biopharmaceutical industry. To date, it has served over 500 advanced international and domestic innovative pharmaceutical companies, research institutions, and medical organizations. Its products are exported to Europe and the United States, with cumulative sales exceeding one billion units.

 

The group's headquarters is located in Yangpu District, Shanghai, with R&D centers in Shanghai, Hong Kong, and Cambridge, UK. It has established branches and subsidiaries in multiple cities, including Beijing, Guangzhou, Wuhan, Nanjing, Suzhou (technical service base), Dezhou (northern production base), Nanchang, and Tianjin. The company has received strategic investments from AstraZeneca and the SDIC Fund.

 

Today, leveraging deep organoid resource development and AI data modeling, bioGenous is emerging as a leading enterprise driving the transition of innovative model methodologies from research-grade breakthroughs to pharmaceutical-grade applications.

  • Our Mission

    To be a global pioneer in organoid model platforms

  • Our Vision

    Pioneer Pharma Innovation, Democratize Model Value

  • Our Value

    Resilience Integrity Focus Responsibility

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Development
2010
2015
2018
2019
2020
2021
  • The First Organoid Construction in China

    The founding team successfully constructed intestinal organoids at Tsinghua University.
  • The First High-level Organoid Paper in China

    The founding team applied organoid technology in a paper published in the journal Nature Communications.
  • Multi-lineage and Multi-cancer Standardized Organoid Technology

    Establishing normal and tumor organoid cultures for endodermal organs, achieving industrial translation.
  • Standardized Reagents and Assay Kits are Now Available

    Organregen® GMP-Grade, Stable Strain Growth Factor Pipeline Established, Comprehensively Advancing Organoid Research. bioGenous™ Organoid Multi-Cancer, Whole-Process Kits Now Available
  • Leading International Organoid Construction for COVID-19 Infection Models

    In March 2020, the team successfully constructed the worlds first human-derived organoid model of SARS-CoV-2 infection, which was featured in an interview by Nature and highlighted on its homepage.
  • Serving Multiple Leading Innovative Pharmaceutical Companies in the Country

    Collaborating with leading domestic companies in specialized segments of the innovative drug industry to create successful cases of new drug R&D and non-clinical evaluation systems using organoids.
Model Revolution-Organoid
2009
Hans Clevers' team established the world's first “intestinal organoid”
2013
Science magazine's “Top Ten Breakthroughs of the Year”
2017
Organoids were selected as the Method of the Year by Nature Methods
2018
The first international report on a colorectal cancer organoid drug sensitivity screening system, with a positive predictive accuracy of 88% (Science)
2020
Organoids entered the EU's “Horizon 2020” strategic plan
Nature reported on how organoids solve the mechanism of SARS-CoV-2 infection
2021
Organoids are included in China's “14th Five-Year” National Key Development Plan
Organoids, as “astronauts in a petri dish”, have been launched to the Chinese space station
The CDE-released 'Technical Guidance Principle for Nonclinical Research and Evaluation of Gene-Modified Cell Therapy Products' proposes for the first time that organoid models can be used to assess efficacy and safety
Advantages of Organoid Models

An organoid is a 3D structure formed by culturing adult stem cells or pluripotent stem cells in vitro, which resembles the tissue from which it is derived. Organoids are highly consistent with their source tissues in terms of tissue structure, cell types, self-renewal capacity, and function. As such, they demonstrate unique advantages in various fields of biomedicine, including developmental biology, disease modeling, precision medicine, drug R&D, gene and cell therapies, infection and immunity, and regenerative medicine.

Comparison among Common Research Models

  Cell line Caenorhabditis elegans Drosophila melanogaster Danio rerio mouse model PDX model human-derived organoids
ease of establishment / ×
ease of maintainence
developmental simulation × ×
experimental cycle
gene manipulation ×
genome-wide screening × ×
physiological complexity ×
experimental cost
simulating the human body
best good partially suitable unsuitable ×
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