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Organoid Metabolomics Analysis and Drug Development
Understanding the mechanisms of tumor-specific activated metabolic pathways is crucial for the development of new tumor drugs. Here, by establishing tumor organoid initiation and development models and combining these with metabolomics analysis during the process, we can conduct more realistic and in-depth studies of specific signaling molecules in metabolic signaling pathways during tumor initiation and development, as well as new target identification and inhibitor drug screening.
Service Process

Service Content and Description

Fields

Tumor Metabolomics Analysis and Drug Screening

 

Keypoints

1) Analyzing metabolic activation/inhibition of organoid;

2) Establishing disease modeling to propose therapeutic solutions/drug screening.

 

Contents

At the organoid level, we establish a strategy to analyze the activation of specific metabolic pathways after the tumorigenesis model of organoids, explore the key factors of specific metabolic activation, and then block the metabolic pathways specifically activated by tumor organoids for treatment.

 

Advancements

1) The important role of metabolic activation/inhibition in tumorigenesis can be precisely analyzed;

2)Analysis of key targets regulating metabolic activation/inhibition during tumorigenesis and elaboration of their regulatory mechanisms;

3)Based on the blocking of tumor-specific metabolic modes, screening drugs with specific blocking effect on tumor metabolism.


Case Studies

Disturbed one-carbon metabolism in hepatoblastoma: S-adenosylmethionine (SAM) is downregulated and S-adenosyl-L-homocysteine (SAH) is upregulated in YAP1-activated hepatoblastoma-like organs.

Methyltransferase inhibitor screen: the small molecule chemotaxis BIX 01294 can inhibit hepatoblastoma by blocking G9a activation and thereby achieving inhibition.

Protein & Cell, 2021, IF=14.9

 

Suitable Scenarios

Metabolomics, organoid gene function studies, tumor metabolomics, tumorigenesis models

 

Related Fields

Tumor metabolism, tumor microenvironment, glycolysis, one-carbon cycle, small molecule inhibitors

 

For more details, please contact:

400-600-8315

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