Fields

Organoid Model of Tumorigenesis

Keypoints

1) Technical services for organoid establishment / organoid strains (high success rate, possibility of long-term transmission, clear genetic background of organoids);

2) Simulation of tumorigenesis at the organoid level;

3) Small molecule amplification culture system for embryonic liver organoids.

Contents

1) Tumorigenesis modeling and interventional drug screening.

2) Establishing normal tissue organoids, and then, based on genetic manipulation technology, knocking down or overexpressing specific genes to simulate the organoid model of cancer; 

3) High-throughput and high-concentration drug screening.

Advancements

1) To simulate the changes in polarity, proliferation, differentiation and metabolism in the process of tumorigenesis, and to simulate the process of obtaining malignant phenotypes from the absence to the presence of tumors at the organoid level;

2) To establish tumor organoids with clear genetic background, which can be used to analyze the influence of single-gene and multi-gene combinations of factors on the occurrence of cancer;

3) for drug screening of specific targets;

4) To reproduce a large number of specific low incidence tumor organoid models.

Applications:

1、Human-derived organoid gene manipulation simulates tumorigenesis and clarifies important cognition in the field of oncology.

Organoid establishment and in situ transplantation of human embryonic hepatoblastoma organoids

2、Research Publications and Patents

Simulation of tumorigenesis and progression, developmental signaling regulation, drug screening

Related Keywords

Tumor in situ transplantation models, tumor organoids, tumor immunotherapy, non-clinical efficacy evaluation, small molecule drug development, tumor inhibitors

For more details, please contact:

400-600-8315