产品介绍
Basement membranes are thin continuous layers of specialized extracellular matrix that form the interface on
which epithelial, endothelial, or neuronal cells grow. Basement membranes also support muscle and Schwann
cells of the peripheral nerves as they are found surrounding these cells. bioGenousTM EasyGel 3D ECM is a
soluble form of basement membrane extracted and purified from the Engelbreth-Holm-Swarm (EHS) tumor. The
major constituents of the bioGenousTM EasyGel 3D ECM include laminin, collagen IV, entactin/nidogen, and
heparin sulfate proteoglycan.
bioGenous™ EasyGel 3D ECM is a reduced growth factor hydrogel specifically optimized for rapid organoid
construction. bioGenous TM EasyGel 3D ECM allows the complete control of the organoid culture
microenvironment to allow for more consistent cell growth and reproducible experiments. It supports the growth
and maintenance of human embryonic stem cells (hESCs), tissue-derived stem cells, and for the in vivo study of
both healthy and tumor organoids derived from various organs.bioGenous™ EasyGel 3D ECM is compatible with
all culture media and gels at temperatures above 10°C to form a reconstituted basement membrane. Notably,
bioGenous™ EasyGel 3D ECM is highly suitable for PDX-derived organoid (PDXO) models, providing an optimal
scaffold for tumor cells isolated from patient-derived xenografts to maintain their original histological architecture,
phenotypic traits, and genetic stability.
