产品列表

联系方式

400-600-8315

info@biogenous.cn

浙江省杭州市萧山区宁围街道传化科创大厦2幢6层

Prostaglandin E2

目录号
C363246
产品规格
{{item.Title}}
现价:¥{{price}}
原价:¥{{oldPrice}}
产品介绍

DESCRIPTION

Background

Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.

Alias

PGE2;前列腺素 E2;地诺前列酮


技术参数

M. W t

352.47

Formula

C₂₀H₃₂O

CAS No

363-24-6

Storage

Powder

-20°C  3 years         

In solvent

-80°C  6 months

-20°C  1 month                             

Solubility

DMSO    

≥ 100 mg/mL(283.71 mM)

 

Ethanol

70 mg/mL(198.60 mM)

 

H2O

< 0.1 mg/mL(insoluble)

BIOLOGICAL ALTIVITY

In Vitro   

PGE2 shows inhibition of IL 2 production in the mixture of irradiated and nonirradiated T lymphocytes. PGE2 (0.1-10 μM) dose-dependently inhibits the production of IL 2. PGE2 acts during the inductive phase of activation of suppressor cells. Preincubation of T lymphocytes with PGE2 induces cells that suppress IL 2 production and PHA proliferation[1].

In Vivo  

PGE2 (0.3 μg/k, i.p.) significantly reduces the number of peritoneab macrophages undergoing phagocytosis of the methacrybate microbeads in rats[2]. PGE2 (0.1 mg/min, i.a.) increases renal blood flow. PGE2 produces a biphasic change in renal vascular resistance, vasodilatation starts at 0.01 mg/min and is maximal at about 3 mg/min, while at the highest dose used (20 mg/min) PGE2 induces renal vasoconstriction[3].

REFERENCES

[1]. Chouaib S, et al. The mechanisms of inhibition of human IL 2 production. II. PGE2 induction of suppressor T lymphocytes. J Immunol. 1984 Apr;132(4):1851-7.

[2]. Fernandez-Repollet E, et al. In vivo effects of prostaglandin E2 and arachidonic acid on phagocytosis of fluorescent methacrylate microbeads by rat peritoneal macrophages. J Histochem Cytochem. 1982 May;30(5):466-70.

[3]. Haylor J, et al. Renal vasodilator activity of prostaglandin E2 in the rat anaesthetized with pentobarbitone. Br J Pharmacol. 1982 May;76(1):131-7.

 

相关产品
分享到微信