bioGenous™ OrganoidpleX Medium (Serum-free) is a well-formulated reduced-serum culture medium intended for the ex vivo coculture and maintenance of organoids and human immune cells, under reduced serum conditions. This medium contains essential nutrients that closely mimic the tumour microenvironment and hence supports the short-term ex vivo maintenance of complex coculture models that involve patient-derived tumour organoids and immune cells such as human peripheral blood mononuclear cells (PBMCs), tumour-infiltrating lymphocytes (TILs), or natural killer cells (NK) during drug screening applications. It is suitable for short-term coculture of immune cells and organoids such as colorectal, gastric, lung cancer, among others.