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浙江省杭州市萧山区宁围街道传化科创大厦2幢6层

Hydrocortisone

目录号
C502370
产品规格
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产品介绍

DESCRIPTION

Background

 

Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

Alias

Cortisol;氢化可的松;17-羟基皮质 () 酮;皮质甾醇;氢化皮质素

M. W t

362.46

Formula

C21H30O5

CAS No

50-23-7

Storage

Powder

-20 °C          

3 years

In solvent

-80 °C   

6 months

-20 °C          

1 month                                       

Solubility

DMSO     

H2O : < 0.1 mg/mL

≥ 31 mg/mL(85.53 mM)

 

 

Ethanol

23 mg/mL(63.46 mM)

 

H2O

< 0.1 mg/mL(insoluble)

BIOLOGICAL ALTIVITY

In Vitro   

Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer[1]. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5[2]. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells[3].

In Vivo

NCT00621985

Boston Children´s Hospital

Adrenal Hyperplasia, Congenital

Phase 2

NCT03910088

Cairo University

Post-Dural Puncture Headache

Phase 4

NCT00657306

University of Turin, Italy

Cirrhosis With Ascites

Phase 2

 

REFERENCES

[1].Förster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49.

[2]. Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9.

[3].Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107(5):776-84.


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