Background

Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase^[1]. Forskolin is also an inducer of intracellular cAMP formation^[2]. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR^[3]. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy^[1][2][3].

Alias

毛喉素; Coleonol; Colforsin

M. W t

410.50

Formula

C₂₂H₃₄O₇

CAS No

66575-29-9

Storage

Powder

-20°C  

3 years                          

In solvent

-80°C 

6 months                                 

-20°C      

1 month

Solubility

DMSO

100 mg/mL(243.61 mM; Need ultrasonic)

Ethanol

82 mg/mL(199.76 mM)

H2O

< 0.1 mg/mL(insoluble)